Leader in HA filler manufacturing


Technology behind our Filler

Hyaluronic acid is a polysaccharides polymer consisting of amino and uronic sugar; it does not have the characteristic of a specie nor organ but is a substance largely available in living bodies such as in the eyeball, comb, skin tissue, placenta and shark cartilage.


Hyaluronic acid shows excellent biocompatibility and high viscoelasticity when implanted or injected; moreover it is used in diverse ways because of its humectant, antibiosis, anti-inflammatory and

lubricating effect.

BioPlus’s HA Filler uses Hyaluronic acid that possesses the physical natures mentioned above, to create a product that shows an increased Cross Linking rate by applying the company’s patented High Technology - resulting in a Filler used widely in petit plastic surgery and skin care that won’t harm the human body when injected and that will not dissolve to provide a

long-lasting shape.


Our product has overcome the conventional

Cross-linking technology by applying the patented Multi-staged Cross-linking technology to create three layered small beads that resolves the difficulty of creating a long-lasting HA Filler. Our product is world’s first semi-permanent HA Filler that has increased the entry barriers by applying core technology so that the HA filler does not transform its component after product completion to keep the human body unharmed.



Thanks to the patented Multi Staged Cross-linking Technology, BioPlus Co., Ltd. achieved in creating a Dermal Filler of 4 stage cross-link through creationg of microbeads. 

This allows for a long-lasting filler eventhough the product itself is 100% Hyaluronic Acid (see Safe & Removable).


the high viscosity and cohesiveness of the product does not easily dissolve the filler through natural hyaluronidase.


Easy molding

Our product shows exceptional volume enhancement due to its outstanding hydrophilic capacity through its stable particle structure. Moreover even with a small amount the product allows for easy molding and with a greater volume enhancement effect.


Our product successfully achieved a high viscous semi-solid Hyaluronic acid gel through the patented Multi-staged Cross-linking Technology overcoming the technological limitations of conventional filler products. It allows for easy molding due to its high viscosity and small particle size.


Strong viscosity

Our product is highly viscous ranging up to 11,000,000 cp. Strong viscosity allows for a long-lasting filler being migration resistant and contributing to the long-lasting effect. 


Safe & Removable

Our Dermal Fillers uses Hyaluronic Acid as base material. According to the Refractive index comparison, the final product shows the exact wavelength pattern as its raw material, proving that our providuct is 100% HA with no chemical alterations during its manufacturing (cross-linking) process.








Moreover our fillers are higly hydrophillic that can be easily dissolved through Hyaluronidase. Although the product itself is long-lasting to natural hyaluronidase, however as the graph below shows fast dissolution of the filler by injection of hyaluronidase.